Ethan He Ageing

Aging: a kind of underlying logic for understanding diseases

Photo Source: Unsplash


It seems that how Alzheimer's disease occurs and how to choose treatment has always been a problem for countless people. It is not only a logical problem of chicken or egg first, but also a philosophical problem of appearance and essence. In addition to the treatment dilemma that makes scientists scratch their heads, clinicians helpless and the general public sad, it also reflects the time trauma that aging brings to everyone. With doubts, the exploration is still going on. Donanemab, a therapeutic drug for amyloid β-protein (Aβ), announced the results of its phase Ⅱ study in patients with early symptoms of Alzheimer's disease. Patients received Donanemab intravenously every four weeks. At 76 weeks, the baseline change of Alzheimer's rating scale (iADRS; Range, 0-144, lower score, indicating that cognitive dysfunction is more serious) score was - 6.86, and that of the placebo group was - 10.6 (the difference was 3.20 [95% CI: 0.12-6.27; p=0.04). Most of the secondary endpoints, such as clinical dementia scale (CDR-SB), 13 item cognitive subscale of Alzheimer's assessment scale (ADAS-Cog13), ADCs iADL and mental state examination (MMSE) scores, did not change significantly (1). Most of the secondary endpoints, such as clinical dementia scale, Alzheimer's assessment scale, 13 item cognitive subscale, ADCs IADL and mental state examination scores, did not change significantly (1). This kind of research is obviously not exciting, the curative effect is not significant, some indicators are good and some are bad, did not let Aβ theory get rid of the shadow of failure. Obviously, the research on Alzheimer's disease cannot be limited to the thinking framework of treat the head when the head aches, treat the foot when the foot hurts. Like many chronic diseases, such as cardiovascular disease and diabetes, maybe aging is the underlying logic, and understanding the essence of aging is the solution.


Aging is a concept with rich connotation. It is not easy to face from biology, ethics to social governance, but it must be faced. From a biological point of view, the characteristics of aging include many aspects, including genomic instability, telomere shortening and loss, epigenetic changes, loss of protein synthesis and metabolic balance, imbalance of nutritional regulation, mitochondrial dysfunction, apoptosis, stem cell failure and changes in intercellular communication. The non-linear accumulation of cell damage in time and space is the essence of aging, which has unity in the seemingly opposite processes of tumor and aging. Building a model to describe aging may be a bigger and unrealistic idea than landing on Mars (2).



1, Mintun MA, et al. N Eng J Med. 2021;384:1691-1704.

2, Lopez-Otin C, et al. Cell. 2013;153:1194-1217.

Share to:
Disclaimer and Agreement

CAVALIER PERSPECTIVE is a medical technology knowledge and opinion management organization. CAVALIER PERSPECTIVE mainly analyzes and shares medical technology knowledge and opinions, and helps scientists engaged in translational medicine research and entrepreneurs in biomedical companies to carry out knowledge innovation, technological innovation and product innovation. Currently, it is unable to provide consulting and business services for most organizations and customers. The website provides information for potential customers, such as researchers, scientists, students, business managers, and industry-related personnel. In any case, any information contained on this website shall not be sold for commercial purposes. This website does not contain any unauthorized data and patents of customers. Some research reports and data provided on this website may not be available to the public without authorization.

To view this content, in addition to using the CAVALIER PERSPECTIVE terms and privacy policy, you must agree to the following terms:

I confirm and agree to CAVALIER PERSPECTIVE:

  • I entered this website only to obtain general information about CAVALIER PERSPECTIVE and not for any other purpose.
  • I understand that the personal data provided by CAVALIER PERSPECTIVE is not open to the public.
  • I understand that certain research report materials on this website will only be provided to a small number of people and organizations that meet the specified standards.
  • I understand that this website has not been reviewed or approved, submitted or otherwise provided by any government or similar agency, and the purpose of this website is only to provide to the public who have a legitimate interest in such information for reasons unrelated to investment Limited information.
  • I understand that when CAVALIER PERSPECTIVE provides third-party information, CAVALIER PERSPECTIVE usually does not have a verified statement made by a third party, and the presentation of information may omit important information.
  • I know that third-party materials, such as provided by on-site interviews or written in their own name, CAVALIER PERSPECTIVE usually does not make changes to these materials on the premise of determining the relevant topics. With the informed consent of the third party, they may be individually based on the semantic context. Sentence editing, which may include providing historical and professional background.
  • The content of CAVALIER PERSPECTIVE has proprietary intellectual property rights or third-party materials, including interviews and licensors of writing, etc. I will guarantee that I will not directly or indirectly copy, modify, rewrite, or create derivative works, including articles, social media , Publish, display, redistribute, disclose or provide content. For all or part of the website content, any content used for commercial purposes requires the written consent of CAVALIER PERSPECTIVE.

By registering the following my information and clicking "Agree", I guarantee that I have read: